Comparative Cytotoxicity of Selected Mikania species using Brine Shrimp Lethality Bioassay and Sulforhodamine B (SRB) Assay
نویسندگان
چکیده
This study aims to assess the comparative cytotoxic activity of ethanolic extract Mikania cordata (MC), micrantha (MM) and scandens (MS) (Family: Asteraceae) using brine shrimp lethality bioassay colorimetric sulforhodamine B assay method. In SRB assay, A549 human lung carcinoma, SK-Mel-2 skin melanoma B16F1 mouse cell lines were used. LC50 for MC, MM, MS vincristine found be 29.04, 15.84, 32.35, 1.2 μg/ml, respectively. The results indicate that all species showed moderate against nauplii. 50% growth inhibition concentration (IC50) cisplatin B16-F1 33, 15, 39 6.8 Similar data observed other indicating cytotoxicity extracts. Among species, M. relatively potent effect followed by scandens. suggest possesses highest potentials among species.
 Bangladesh Pharmaceutical Journal 24(1): 11-16, 2021
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ژورنال
عنوان ژورنال: Bangladesh Pharmaceutical Journal
سال: 2021
ISSN: ['0301-4606', '2408-8463']
DOI: https://doi.org/10.3329/bpj.v24i1.51630